The 350th Civil Affairs Command was first constituted on 16 October 1999 in the Army Reserve as Headquarters and Headquarters Company, 350th Civil Affairs Command, and activated at Pensacola, Florida.
On 16 October 1999, Headquarters and Headquarters Company, 361st Civil Affairs Brigade was inactivated and its personnel re-flagged as the Headquarters and Headquarters Company, 350th Civil Affairs Command.
The Pensacola headquarters unit one of only 4 Civil Affairs Commands in the United States.
At that time, the 350th Civil Affairs Command had over 1,100 personnel under its command, mostly Army Reservists whose civilian expertise was needed to support military efforts abroad.
The 350th Civil Affairs Command was part of the US Army Civil Affairs and Psychological Operations Command at Fort Bragg, North Carolina.
Civil affairs Soldiers are the Army's experts working with civilian authorities and setting up civilian governments in the wake of wars and natural disasters.
The 350th Civil Affairs command was activated to support US Southern Command. The activation ceremony created the fourth civil affairs command in the US Army.
The newly created command absorbed responsibility for the Caribbean region as a result of the transfer of regional responsibility from US Atlantic Command to US Southern Command. The Command could also deploy forces in support of any of the geographical commanders if required.