The 350th Civil Affairs Command was first constituted on 16 October 1999 in the Army Reserve as Headquarters and Headquarters Company, 350th Civil Affairs Command, and activated at Pensacola, Florida.
On 16 October 1999, Headquarters and Headquarters Company, 361st Civil Affairs Brigade was inactivated and its personnel re-flagged as the Headquarters and Headquarters Company, 350th Civil Affairs Command.
The Pensacola headquartered unit is one of only four Civil Affairs Commands in the United States. At the time, the 350th Civil Affairs Command had over 1,100 personnel under its command, mostly Army Reservist Soldiers whose civilian expertise was needed to support military efforts abroad. The 350th Civil Affairs Command was activated as a subordinate unit under the US Army Civil Affairs and Psychological Operations Command at Fort Bragg, North Carolina. The Command was regionally aligned to North American and South American missions but the Command continues to deploy forces in support of all geographical commanders through rotating mission requirements. Civil Affairs Soldiers are the Army's experts working with civilian authorities and setting up civilian governments in the wake of wars and natural disasters.